NegGOA: negative GO annotations selection using ontology structure
نویسندگان
چکیده
منابع مشابه
Importance of Secondary Structure Elements for Prediction of Go Annotations
Predicted or actual protein secondary structure, in addition to amino acid sequence, is often used for fold recognition and function prediction. Different kinds of secondary structure elements could be predicted with different accuracy by different prediction methods and this could affect the fold or function prediction performance. In this study, contribution of amino acid sequence residues be...
متن کاملVisualizing GO Annotations.
Contemporary techniques in biology produce readouts for large numbers of genes simultaneously, the typical example being differential gene expression measurements. Moreover, those genes are often richly annotated using GO terms that describe gene function and that can be used to summarize the results of the genome-scale experiments. However, making sense of such GO enrichment analyses may be ch...
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MOTIVATION New biological systems technologies give scientists the ability to measure thousands of bio-molecules including genes, proteins, lipids and metabolites. We use domain knowledge, e.g. the Gene Ontology, to guide analysis of such data. By focusing on domain-aggregated results at, say the molecular function level, increased interpretability is available to biological scientists beyond w...
متن کاملVisualizing Gene Ontology annotations
Contemporary techniques in biology produce readouts for large numbers of genes simultaneously, the typical example being differential gene expression measurements. Moreover, those genes are often richly annotated using GO terms that describe gene function and that can be used to summarize the results of the genome-scale experiments. However, making sense of such GO enrichment analyses may be ch...
متن کاملThe Gene Ontology Annotation database (GOA): A community resource of GO annotations to the UniProt Knowledgebase
The Gene Ontology Annotation (GOA) database (http://www.ebi.ac.uk/GOA) provides highquality electronic and manual annotations to the UniProt Knowledgebase using the standardized vocabulary of the Gene Ontology (GO). As a supplementary archive of GO annotation, GOA promotes a high level of integration of the knowledge represented in UniProt with other databases. This is achieved by converting Un...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2016
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btw366